Top 15 Pharmaceutical Companies in the World ranked by sales revenue for 2025

This ranking is based exclusively on pharmaceutical drug and vaccine sales revenue, as reported in each company’s 2024 annual report. Revenue from other business segments, etc such as:

• Roche’s diagnostics
• J&J’s MedTech
• MSD’s animal health
• Bayer’s crop science and consumer health

was excluded to ensure a focus solely on pharmaceutical sales from PLCs.

2024 Pharmaceutical Drug & Vaccine Sales Revenue (USD Billions) 

1. 1. Pfizer (US) – $63.6B
   2. J&J (US) – $57.80B
   3. Merck & Co. (US) – $57.4B
   4. Roche (Switzerland) – $57.16B
   5. AbbVie (US) – $56.33B
   6. AstraZeneca (Sweden/UK) – $54.1B
   7. Novartis (Switzerland) – $50.3B
   8. Sanofi S.A. (France) – $47.32B
   9. Bristol-Myers Squibb (US) – $46.4B
   10. Eli Lilly (US) – $45.4B
   11. Novo Nordisk (Denmark) – $44.80B
   12. GlaxoSmithKline (UK) – $41.25B
   13. Amgen Inc. (US) – $33.4B
   14. Takeda (Japan) – $29.7B
   15. Gilead Sciences (US) – $28.7B

• Revenue
  • 2024: $28.70 billion
  • 2023: $27.12 billion
  • 2022: $27.81 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $5.97 billion
• Number of employees: 17,600
• Revenue per employee: $1,630,000

Gilead was founded in 1987 in California, US and since then, has grown to become one of the world’s largest biopharmaceutical companies. They are a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines. Gilead Sciences focused on virology, hepatology, haematology, oncology, cardiovascular, inflammation and respiratory diseases.

Ref: Gilead Sciences Annual Report 2024

• Revenue
  • 2024: $29.7 billion (¥4,581 billion)
  • 2023: $30.30 billion
  • 2022: $29.40 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $4.73 billion
• Number of employees: 47,445
• Revenue per employee: $612,000

Takeda Pharmaceutical Company is a Japanese multinational pharmaceutical company and one of the top 20 largest pharmaceutical companies in the world by revenue (following the merger with Shire). The company is focused on metabolic disorders, gastroenterology, neurology, inflammation, as well as oncology through its independent subsidiary, Takeda Oncology.

Ref: Takeda Annual Report 2024

• Revenue
  • 2024: $33.4 billion
  • 2023: $28.20 billion
  • 2022: $24.81 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $6 billion
• Number of employees: 28,800
• Revenue per employee: $1,159,000

Amgen Inc. is an American multinational biopharmaceutical company headquartered in California, United States and is one of the world’s largest independent biotechnology firm. In 2013, the company’s largest selling product lines were Neulasta/Neupogen, two closely related drugs used to prevent infections in patients undergoing cancer chemotherapy; and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.

Ref: Amgen Inc Annual Report 2024

• Revenue
  • 2024: $41.25 billion (£31.40 billion)
  • 2023: $37.76 billion
  • 2022: $36.75 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $8.4 billion
• Number of employees: 68,600
• Revenue per employee: $601,000

GlaxoSmithKline plc is a multinational company based in the United Kingdom dealing in the fields of pharmaceuticals, biologics, vaccines and consumer healthcare. GSK was formed by the merger of Glaxo Wellcome plc and SmithKline Beecham plc in 2000. It manufactures products for various diseases including mental health, diabetes, asthma, cancer, virus control, etc. GSK also manufactures nutritional products, drinks, and other healthcare goods like Horlicks, Sensodyne, Boost, etc. Its top-selling drug is Advair and is used to treat asthma and chronic obstructive pulmonary disorder treatment. Although GSK’s total revenue decreased from $44.75 billion in 2021 to $36.75 billion in 2022, that can be attributed to it separating from its consumer health unit Haleon.

Ref: GlaxoSmithKline plc Annual Report 2024

• Revenue
  • 2024: $44,80 billion (Dkk290,400 million)
  • 2023: $33.30 billion
  • 2022: $25.40 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $7.40 billion
• Number of employees: 77,340
• Revenue per employee: $579,200

Novo Nordisk is a Danish pharmaceutical company founded in 1923, with global headquarters in the Danish town of Bagsvaerd. Its key products are diabetes care medication. Over 29 million patients use their products and the company produces almost 50% of the world’s insulin. Novo Nordisk’s revenues increase dramatically mostly due to demand for its diabetes and obesity products Ozempic and Wegovy.

Ref: Novo Nordisk Annual Report 2024

• Revenue
  • 2024: $45.4 billion
  • 2023: $34.12 billion
  • 2022: $28.54 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D Spend: $10.9 billion
• Number of Employees: 47,000
• Revenue Per Employee: $974,000

Eli Lilly is an American global pharmaceutical company. It was founded by Eli Lilly in 1876 and has its headquarters in Indianapolis, Indiana in the United States. The world owes Lilly for the first mass production of Penicillin, Salk Polio vaccine and insulin and is the largest producer and distributor of psychiatric medications in the world. Other drugs produced by Lilly are namely Mounjaro, Trulicity, Zepbound, Verzenio, etc.

Ref: Eli Lilly Annual Report 2024

• Revenue
  • 2024: $46.4 billion
  • 2023: $45.06 billion
  • 2022: $46.2 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $11,599 billion
• Number of employees: 34,050
• Revenue per employee: $1,360,000

Bristol-Myers Squibb was formed in 1989 through the merger of the Squibb Corporation and Bristol Myers and Company. Today, it has its headquarters in New York City, US and produces pharmaceuticals and biologics for the treatment of a number of conditions including HIV and hepatitis. They were also one of the first companies to begin research and development into anti-cancer drugs in the 1970s.

Ref: Bristol-Myers Squibb Annual Report 2024

• Revenue
  • 2021 (Pharmaceutical drug and vaccine sales): $47.32 billion(€41.08 billion)
  • 2023 (Pharmaceutical drug and vaccine sales): $40.56 billion
  • 2022 (Pharmaceutical drug and vaccine sales): $40.50 billion
• Estimated R&D spend: $8.5 billion
• Number of employees: 82,880
• Revenue per employee: $57,000

Sanofi is a French multinational pharmaceutical company with its headquarters located in Paris, France. It conducts research and development and manufactures pharmaceutical products sold primarily in the prescription market. Over-the-counter medicines are also developed by the company. Various drugs manufactured by the company include Aflibercept, Jevtana, Humenza vaccine, Iniparib and Otamixaban. Sanofi-Aventis was formed in 2004 by the merger of Aventis and Sanofi-Synthélabo and later in 2011 changed the name to Sanofi.

Ref: Sanofi S.A. Annual Report 2024

• Revenue
  • 2024: $50.30 billion
  • 2023: $45.44 billion
  • 2022: $50.54 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $10.2 billion
• Number of employees: 75,800
• Revenue per employee: $663,000

Novartis International AG, a multinational pharmaceutical company is based in Basel, Switzerland. Novartis has been on the face of the pharmaceutical industry for about 250 years owing to its formation by the merger of Swiss companies Ciba-Geigy and Sandoz Laboratories in 1996. Novartis produces a range of products including vaccines, contact lenses, over-the-counter drugs, veterinary medicines, etc. Novartis is a manufacturer of drugs including Clozapine, Diclofenac, Carbamazepine, Valsartan (Diovan) and Glivec.In 2023 Novartis sold Sandoz which did lead to a drop in total revenue but boosted revenue per employee by 20%.

Ref: Novartis International AG Annual Report 2024

• Revenue
  • 2024: $54.1 billion
  • 2023: $45.8 billion
  • 2022: $44.4 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $13.6 billion
• Number of employees: 89,900
• Revenue per employee: $601,700

AstraZeneca plc was founded in 1999, through the merger of the Sweden-based Astra AB and the UK-based Zeneca Group, is a Swedish-British multinational pharmaceutical and biologics company. It specializes in prescriptive medicines including Carbocaine, Naropin, Betaloc, Zestril, Lexinor, Cubicin, Zomig, Tomudex, and a variety of other medicines in the areas of oncology, neuroscience, gastrointestinal, etc. The acid reflux medication called Nexium is its leading product. It is also the manufacturer of drugs for cholesterol treatment called Crestor and an antipsychotic drug called Seroquel.

Ref: AstraZeneca plc Annual Report 2024

• Revenue
  • 2024: $56.33 billion
  • 2023: $54.32 billion
  • 2022: $58.00 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $12.79 billion
• Number of employees: 55,000
• Revenue per employee: $1,024,000

AbbVie is an American biopharmaceutical company formed in 2013 and was formed when Abbott Laboratories announced its plan to separate into two publicly traded companies. It was decided that the “new” Abbott Laboratories would specialize in diversified products including medical devices, diagnostic equipment and nutrition products, while AbbVie would operate as a research-based pharmaceutical manufacturer that specialises in making small molecule drugs for patients worldwide.

The company focuses on therapy areas such as dermatology, oncology, neurological disorders and metabolic diseases.

AbbVie’s most well known for its rheumatoid arthritis med Humira along with Imbruvica, Lupron, Veikira and Synthroid.

Ref: AbbVie Inc Annual Report 2024

• Revenue
  • 2024 (Pharmaceutical Drug Sales): $57.16 billion(CHF46.171 billion)
  • 2023 (Pharmaceutical Drug Sales): $48.7 billion
  • 2022 (Pharmaceutical Drug Sales): $49.9 billion
• 2024 total revenue: $74.9 billion
• Percent of revenue from pharmaceutical drug sales: 76%
• Estimated R&D spend: $16.1 billion
• Number of employees: 103,600
• Revenue per employee: $722,900

Hoffmann-La Roche is a Swiss global healthcare company founded by Fritz Hoffmann-La Roche after whom the company is named, in 1896. Its headquarters is located in Basel, Switzerland. Other companies owned by Roche are Genentech, Chugai pharmaceuticals and Ventana. It was the first company to produce synthetic vitamin C at a large scale under the brand name of Redoxon. Its leading drug is Herceptin a medication for breast cancer. The various drugs produced by Roche include Accutane, Bactrium, Cellcept, Herceptin, Invirase, Tamiflu, Rohypnol, etc. It also manufactures a range of Diabetes management products under the brand name Accu-check.

Ref: Hoffman-La Roche AG Annual Report 2024

• Revenue
  • 2024 (revenue from pharmaceutical drug sales): $57.4 billion
  • 2023 (revenue from pharmaceutical drug sales): $53.58 billion
  • 2022 (revenue from pharmaceutical drug sales): $52.05 billion
• 2024 total revenue: $64.16 billion
• Percent of revenue from pharmaceutical drug sales: 89%
• Estimated R&D spend: $17.93 billion
• Number of employees: 75,000
• Revenue per employee: $855,000

Merck & Co., Inc is an American pharmaceutical company with its headquarters located in Whitehouse Station, New Jersey. Kenneth Frazier is the chairman, president and CEO of the company and it was founded in 1891 as a subsidiary of Merck KGaA. It came out as an independent company in 1917 after being taken over by the US Government during World War I.

Ref: Merck & Co, Inc Annual Report 2024

• Revenue
  • 2024 (Pharmaceutical drug and vaccine sales): $57.80 billion
  • 2023 (Pharmaceutical drug and vaccine sales): $54.80 billion
  • 2022 (Pharmaceutical drug and vaccine sales): $52.60 billion
• Percent of revenue from pharmaceutical drug sales: 64.3%
• Estimated R&D spend: $14.60 billion
• Number of employees: 138,000
• Revenue per employee: $634,000

Johnson & Johnson is a US-based multinational company that manufactures medical devices, pharmaceuticals and consumer packaged goods. It was founded in 1886 by Robert wood Johnson I, James Wood Johnson and Edward Mead Johnson. The Company’s headquarters is located in New Brunswick, New Jersey. Johnson & Johnson is a leading name in many household items like Johnson & Johnson baby products, Neutrogena skin and beauty products, Band-Aid, Clean and clear facewashes, etc. The other drugs manufactured by it are Bapineuzumab, Ceftobiprole, Dacogen, Procrit, Rivaroxaban, Topamax, etc.

Ref: Johnson & Johnson Annual Report 2024

• Revenue
  • 2024: $63.6 billion
  • 2023: $58.5 billion
  • 2022: $100.3 billion
• Percent of revenue from pharmaceutical drug sales: 100%
• Estimated R&D spend: $10.82 billion
• Number of employees: 88,000
• Revenue per employee: $722,720

Pfizer is the world’s largest research-based pharmaceutical company. Its research headquarters are located in Groton, Connecticut, America. Pfizer has developed many medicines and vaccines like Sutent, Zithromax, apixaban, Macugen, Lyrica, Latreperdine, etc. in the areas of oncology, infections and infestations, cardiology, ophthalmology, neurology and psychiatry. Its top-selling product is ELIQUIS® which makes up 12% of revenue. The company was founded in 1849 in New York City by cousins Charles Pfizer and Charles Erhart.

Ref: Pfizer Inc Annual Report 2024